Dabigatran is a selective, competitive, direct inhibitor of thrombin factor iia while. Be able to describe the biochemical mechanisms of action, therapeutic uses, contraindications and adverse effects of the specific anticoagulant and fibrinolytic agents listed above. Worlds best powerpoint templates crystalgraphics offers more powerpoint templates than anyone else in the world, with over 4 million to choose from. Define how different classes of anticoagulant and fibrinolytic drugs interact with specific clotting factors and naturally occurring anticoagulants in the context of. Learn vocabulary, terms, and more with flashcards, games, and other study tools. Antithrombotic therapy and prevention of thrombosis, 9th ed. The first drugs designed to inhibit platelets or coagulation factors, such as the antiplatelet clopidogrel and the anticoagulant warfarin, significantly reduced the risk of thrombotic events at the. It is a racemic mixture of two optically active isomers r and s in equal proportion. To get a better understanding on the topic, you can read about antiplatelet agents and thrombolytic drugs.
Data sources include ibm watson micromedex updated 4 may 2020, cerner multum updated 4 may 2020, wolters kluwer updated. Because of the predominance of platelets and fibrin in thrombi, antithrombotic drugs used to treat thrombosis include antiplatelet drugs, which inhibit platelet activation or aggregation, anticoagulants, which attenuate fibrin formation, and fibrinolytic agents, which degrade fibrin. Antithrombotic drugs used to treat thrombosis include antiplatelet drugs, which inhibit platelet activation or aggregation. Plateletaggregation inhibition is not significant until after approximately 4 days of regular dosing. Reversal strategies for intracranial hemorrhage related to. Intrinsic pathway extrinsic pathway tissue injury blood vessel injury recall.
The validity of therecommendation made at the earlier conferences, that the intensity ofwarfarin treatment should be reduced for many. The anticoagulant influence of warfarin is generally monitored every 24 weeks initially, but in stable patients may be evaluated every 23 months. Critical facts if med school is a minnesota forest with millions of trees, these are the red pines 1. Xiia xii thromboplastin xia xi ixa ix viia xa x factors affected by heparin prothrombin vit. Syed shariq naeem, senior resident doctor, department of clinical pharmacology, maulana azad medical college, new delhi india download to play animations.
Composed of platelet aggregates, fibrin, and trapped red blood cells, thrombi can form in arteries or veins. Anticoagulant, thrombolytic, and antiplatelet drugs. Anticoagulant mechanism, pharmacological activity, and. Adverse side effects of doacs may result in hemorrhagic complications, including lifethreatening intracranial hemorrhage ich, though to a much lesser. However, for adequate anticoagulation one needs to reduce the other coagulation factors appropriately, including factor ii prothrombin which has a 60 hour half life. Platelet function returns to normal within 12 weeks as new platelets replace. Learn anticoagulant drugs pharmacology anticoagulants with free interactive flashcards.
A free powerpoint ppt presentation displayed as a flash slide show on id. Its pharmacokinetic and pharmacodynamic pkpd properties are shown in tables 1 and 2. Title slide of pharmacology anticoagulation slideshare uses cookies to improve functionality and performance, and to provide you with relevant advertising. Of these clotting factors, thrombin iia and activated factor x xa are believed to play the most critical role in hemostasis. American college of chest physicians evidencebased clinical practice guidelines. Direct oral anticoagulants doacs such as the direct factor xa inhibitors rivaroxaban, apixaban, edoxaban or the direct thrombin inhibitor dabigatran are attractive treatment options for hit 811 for several reasons. This book aims to explain how scientists unravel the many different ways medicines work in the body and how this information guides the hunt for drugs of the future. Set 1 powerpoint links collected from the website of. Anticoagulation pharmacology kimberly chapin, pharm.
It takes several days after initiation of warfarin therapy to reduce factor ii and thus warfarin and heparin need to overlap for approximately 45 days when starting therapy. View coagulant and anticoagulant drugs ppts online, safely and virusfree. Blood must remain fluid within the vasculature and yet clot quickly when exposed to subendothelial surfaces at sites of vascular injury. Due to their mechanism of action, the new oral anticoagulants are named direct oral anticoagulants doacs. A power point presentation on the fundamentals of anticoagulant drugs suitable for ug level medical students. Ppt pharmacology powerpoint presentation free to view. Anticoagulant therapy has become increasingly common as more indications for anticoagulation such as coronary artery stent placement have arisen. Direct oral anticoagulants doacs are a new class of anticoagulants that directly inhibit either thrombin or factor xa in the coagulation cascade. Anticoagulant therapy principles and practice of hospital medicine. Pharmacology is a broad discipline encompassing every aspect of the study of drugs, including their discovery and development and the testing of their action in the body. Blood coagulation and anticoagulant, fibrinolytic, and antiplatelet. Pharmacology anticoagulant, antiplatelet, and thrombolytic medications patients receiving any of the anticoagulant, antiplatelet, or thrombolytic medications are at. Contents blood coagulation anticoagulants classes of anticoagulants uses of anticoagulants indirectacting directacting surgery in patients receiving anticoagulant therapy the use of anticoagulants in pregnancy blood coagulation blood coagulation means the conversion of fluid blood to a solid gel or clot. Anticoagulant, antithrombotic and antiplatelet drugs.
With their ubiquitous use, it becomes important for clinicians to have a sound understanding of anticoagulant pharmacology, dosing, and toxicity. Anticoagulants can be obtained naturally or derived synthetically. Hemorrhage is the main concerning adverse event with all anticoagulants. This anticoagulant removes the free calcium ion from solution through the addition of ammonium and potassium oxalate. Image were created or taken from wikimedia commons i created this video with the youtube. First, there is no potentially deleterious immunologic interaction between these agents and hit antibodies. An overview of the anticoagulant drugs used in routine clinical.
Ppt anticoagulant drugs powerpoint presentation free. Pdf pharmacology and mechanisms of action of new oral. Heparin was the initial anticoagulant developed and used in clinical care. The anticoagulant mechanism of lunathrombase appears to differ from that of the currently available anticoagulant drugs such as heparin and. Find powerpoint presentations and slides using the power of, find free presentations research about xarelto ppt. Anticoagulants and antiplatelet drugs clinical pharmacology. View and download powerpoint presentations on xarelto ppt.
Blood coagulation and anticoagulant, fibrinolytic, and. Clinical pharmacology of oral anticoagulants in patients. Winner of the standing ovation award for best powerpoint templates from presentations magazine. Anticoagulants, thrombolytics agents and antiplatelet drugs. Sulfated mucopolysaccharides heterogenous mechanism of action. Pharmacologyanticoagulants wikibooks, open books for an. Stroke and myocardial infarction rank among the most frequent causes of death due to cardiovascular diseases. The following points highlight the top five anticoagulants that are commonly used in hematology. Anticoagulants an anticoagulant is a drug that helps prevent the clotting coagulation of blood. Department of pharmacology university of michigan medical school mode of action of antiplatelet agents ticlopidine ticlid platelet inhibition is irreversible. Anticoagulant drugs directly or indirectly influence coagulation factors preventing fibrin formation thus. Example of naturally obtained anticoagulant is heparin while synthetically derived are warfarin, sodium citrate etc. Anticoagulant, thrombolytic, and antiplatelet drugs katzung 9th ed. Download pharmacology powerpoint lectures download free online book chm pdf.
Choose from 500 different sets of anticoagulant drugs pharmacology anticoagulants flashcards on quizlet. Brahma department of pharmacology neigrihms, shillong 2. Anticoagulants drugs that help prevent the clotting coagulation of blood coagulation will occur. Discusses mechanism of action, dosing and target inrs, drug and food interactions, and patient counseling. Theyll give your presentations a professional, memorable appearance the kind of sophisticated look that todays audiences expect.
Antiplatelet, anticoagulant and thrombolytic drugs at. Coagulant and anticoagulant drugs powerpoint ppt presentations. Lyse thrombi by catalyzing plasmin serine protease formation from plasminogen the zymogen precursor. Here are a couple of questions related to the pharmacology of coagulation. It is also a valuable tool for clinicians providing a description of the mode of action and management of therapy for anticoagulant drugs used in daily clinical practice in different clinical settings, including direct oral anticoagulants dabigatran. Chapter 34 this version has been changed compared to the one made available on wednesday april 26 sorry. Identify purpose and use of anticoagulant, antiplatelet, and thromboembolytic agents. Warfarin is the oral anticoagulant with which clinicians have the most experience. The goodman and gilman has 15 sections covering 65 chapters and appendices which are listed as below. Know the properties of agents that can reverse the actions of heparin and the oral anticoagulants. Warfarin powerpoint presentation cme at pharmacology corner. The causes are blocked vessels and the resulting insu. Under normal circumstances, a delicate balance between coagulation and fibrinolysis prevents both thrombosis and hemorrhage. Anticoagulant medications have served as the principle therapy to prevent thrombosis for a variety of cardiovascular diseases over many years.
These drugs tend to prevent new clots from forming or an existing clot from enlarging. Anticoagulant presentation coagulation body fluids. It is also a valuable tool for clinicians providing a description of the mode of action and management of therapy for anticoagulant drugs used in daily clinical practice in different clinical settings, including direct oral anticoagulants dabigatran, rivaroxaban. Additionally, newer anticoagulant therapies have improved management and dosing of anticoagulants.
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